[HTML][HTML] RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial–mesenchymal transition and promotes metastasis of colorectal cancer
C Xiao, G Wu, Z Zhou, X Zhang, YP Wang, G Song… - Cell death & …, 2019 - nature.com
RBBP6 has been implicated in tumorigenesis but its role in tumor metastasis and
progression has not been evaluated. Interestingly, here we show that RBBP6 is upregulated
in colorectal cancer (CRC) where its expression level is positively correlated with distant
metastasis. In this study, we identified RBBP6, a RING Finger-domain E3 ubiquitin ligase,
served as an independent prognostic factor and predicted poor outcome for CRC patients.
RBBP6 promoted cell proliferation, migration, and invasion in CRC cells and promoted …
progression has not been evaluated. Interestingly, here we show that RBBP6 is upregulated
in colorectal cancer (CRC) where its expression level is positively correlated with distant
metastasis. In this study, we identified RBBP6, a RING Finger-domain E3 ubiquitin ligase,
served as an independent prognostic factor and predicted poor outcome for CRC patients.
RBBP6 promoted cell proliferation, migration, and invasion in CRC cells and promoted …
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